This work is licensed under a Creative Commons Attribution 4.0 International License.
Aurein2.6
General Information
DCTPep ID DCTPep00006
Peptide Name Aurein2.6
Sequence GLFDIAKKVIGVIGSL
Sequence Length 16
UniProt ID P82393
PubChem CID Not available
Origin Southern bell frog
Type Native peptide
Classification
ACP Tumor active peptide Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Brain tumor cell (NCI) | Brain tumor | LC50=10 µM | Not available | Not available | 1 |
| Breast tumor cell (NCI) | Breast tumor | LC50=10 µM | Not available | Not available | 1 |
| Lung tumor cell (NCI) | Lung tumor | LC50=10 µM | Not available | Not available | 1 |
| Ovary tumor cell (NCI) | Ovary tumor | LC50=10 µM | Not available | Not available | 1 |
| Prostate tumor cell (NCI) | Prostate tumor | LC50=10 µM | Not available | Not available | 1 |
| Renal tumor cell (NCI) | Renal tumor | LC50=10 µM | Not available | Not available | 1 |
| Skin tumor cell (NCI) | Skin tumor | LC50=10 µM | Not available | Not available | 1 |
| Colon tumor cell (NCI) | Colon tumor | LC50=10-100 µM | Not available | Not available | 1 |
| Leukemia tumor cell (NCI) | Leukemia tumor | LC50=10-100 µM | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Anticancer activity is due to penetration and disruption of the membranes of the cancer cells
Structure Information
PDB ID Not available
Predicted Structure DCTPep00006
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C77H132N18O20
Absent amino acids CEHMNPQRTWY
Theoretical pI 8.59
Acidic residues 1
Basic residues 2
Polar residues 4
Molecular weight (Average) 1630
Molecular weight (Monoisotopic) 1628.99
Common amino acids GI
Net charge 1
Instability index (II) 11.78
Aliphatic index 164.38
Grand average of hydropathicity (GRAVY) 1.300
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 10951191
Title The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2
Doi 10.1046/j.1432-1327.2000.01536.x
Year 2000
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_780
This work is licensed under a Creative Commons Attribution 4.0 International License.