This work is licensed under a Creative Commons Attribution 4.0 International License.
Aurein 3.1
General Information
DCTPep ID DCTPep00008
Peptide Name Aurein 3.1
Sequence GLFDIVKKIAGHIAGSI
Sequence Length 17
PubChem CID Not available
Origin Southern bell frog
Type Native peptide
Classification
ACP Tumor active peptide Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Colon tumor cell (NCI) | Colon tumor | LC50=10 µM | Not available | Not available | 1 |
| Leukemia tumor cell (NCI) | Leukemia tumor | LC50=10 µM | Not available | Not available | 1 |
| Lung tumor cell (NCI) | Lung tumor | LC50=10 µM | Not available | Not available | 1 |
| Prostate tumor cell (NCI) | Prostate tumor | LC50=10 µM | Not available | Not available | 1 |
| Brain tumor cell (NCI) | Brain tumor | LC50=10-100 µM | Not available | Not available | 1 |
| Breast tumor cell (NCI) | Breast tumor | LC50=10-100 µM | Not available | Not available | 1 |
| Ovary tumor cell (NCI) | Ovary tumor | LC50=10-100 µM | Not available | Not available | 1 |
| Renal tumor cell (NCI) | Renal tumor | LC50=10-100 µM | Not available | Not available | 1 |
| Skin tumor cell (NCI) | Skin tumor | LC50=10-100 µM | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Anticancer activity is due to penetration and disruption of the membranes of the cancer cells
Structure Information
PDB ID Not available
Predicted Structure DCTPep00008
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C81H135N21O21
Absent amino acids CEMNPQRTWY
Theoretical pI 8.60
Acidic residues 1
Basic residues 3
Polar residues 4
Molecular weight (Average) 1739.09
Molecular weight (Monoisotopic) 1738.01
Common amino acids I
Net charge 2
Instability index (II) 30.84
Aliphatic index 143.53
Grand average of hydropathicity (GRAVY) 0.935
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 10951191
Title The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2
Doi 10.1046/j.1432-1327.2000.01536.x
Year 2000
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.