This work is licensed under a Creative Commons Attribution 4.0 International License.
Hepcidin-20
General Information
DCTPep ID DCTPep00014
Peptide Name Hepcidin-20
Sequence ICIFCCGCCHRSKCGMCCKT
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Homo sapiens; Pan troglodytes; Pongo pygmaeus; Gorilla gorilla; Nomascus concolor; Hylobates lar
Type Native peptide
Classification
Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL16 positive; Chronic myeloid leukemia | 12% Killing=30 µM | Trypan blue assay | 15 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00014
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys2<--->Cys18; Cys5<--->Cys8; Cys6<--->Cys14; Cys9<--->Cys17
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C85H143N27O23S9
Absent amino acids ADELNPQVWY
Theoretical pI 8.53
Acidic residues 0
Basic residues 4
Polar residues 12
Molecular weight (Average) 2199.78
Molecular weight (Monoisotopic) 2197.83
Common amino acids C
Net charge 4
Instability index (II) 47.77
Aliphatic index 39.00
Grand average of hydropathicity (GRAVY) 0.795
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 500
Abs 0.1% (=1 g/l) 0.227, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 11113131
Title Hepcidin, a urinary antimicrobial peptide synthesized in the liver
Year 2001
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.