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maximin 3
General Information
DCTPep ID DCTPep00016
Peptide Name maximin 3
Sequence GIGGKILSGLKTALKGAAKELASTYLH
Sequence Length 27
UniProt ID Q58T80 Q8JHE1 Q58T83 P83082 Q58T40 Q58T43 Q58T46 Q58T64 B5L0Z8 C3RSY4 C3RSY3 B5L157 B5L154 B5L135 B5L133 B5L106 B5L104 B5L100 B5L0Z5 B5L0Z3 B5L0Z2 B5L0Z1 B5L0Y9 Q58T48 B5L145
PubChem CID Not available
Origin Bombina maxima
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| C8166 | Adult T acute lymphoblastic leukemia | IC50=11.4 µg/ml | MTT assay | 48 h | 1 |
| T24 | Bladder carcinoma | IC50=18 µg/ml | MTT assay | 48 h | 1 |
| Molt-4 | Adult T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | IC50=25.2 µg/ml | MTT assay | 48 h | 1 |
| BIU-87 | Bladder carcinoma | IC50=28 µg/ml | MTT assay | 48 h | 1 |
Hemolytic Activity Had little hemolytic activity to red blood cells even with the concentration of the peptides up to 50 μg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 6HZ2
Predicted Structure DCTPep00016
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C122H209N33O35
Absent amino acids CDFMNPQRVW
Theoretical pI 9.83
Acidic residues 1
Basic residues 5
Polar residues 10
Molecular weight (Average) 2698.2
Molecular weight (Monoisotopic) 2696.56
Common amino acids GL
Net charge 4
Instability index (II) -0.68
Aliphatic index 115.93
Grand average of hydropathicity (GRAVY) 0.244
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.552
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 11835991
Title Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima
Doi 10.1016/s0196-9781(01)00641-6
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_835
This work is licensed under a Creative Commons Attribution 4.0 International License.