Peptide Libraray

maximin 4

General Information

DCTPep ID DCTPep00017

Peptide Name maximin 4

Sequence GIGGVLLSAGKAALKGLAKVLAEKYAN

Sequence Length 27

UniProt ID P83083 Q58T79 Q58T52 Q58T42 Q58T44 Q58T62 Q58T77 B5L113 C3RTJ1 B5L130 C3RSS2 C3RSS3 C3RSY5 C3RSY6 C3RSY7 C3RSY8 C3RTJ5

PubChem CID Not available

Origin Bombina maxima

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
C8166	Adult T acute lymphoblastic leukemia	IC50=24.2 µg/ml	MTT assay	48 h	1
Molt-4	Adult T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	IC50=35.4 µg/ml	MTT assay	48 h	1
BIU-87	Bladder carcinoma	IC50>50 µg/ml	MTT assay	48 h	1
T24	Bladder carcinoma	IC50>50 µg/ml	MTT assay	48 h	1

Hemolytic Activity Had little hemolytic activity to red blood cells even with the concentration of the peptides up to 50 μg/ml

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID 2MHW

Predicted Structure DCTPep00017

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C119H206N32O33

Absent amino acids CDFHMPQRTW

Theoretical pI 9.83

Acidic residues 1

Basic residues 4

Polar residues 8

Molecular weight (Average) 2613.14

Molecular weight (Monoisotopic) 2611.54

Common amino acids A

Net charge 3

Instability index (II) 7.25

Aliphatic index 130.37

Grand average of hydropathicity (GRAVY) 0.593

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.570

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 11835991

Title Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima

Doi 10.1016/s0196-9781(01)00641-6

Year 2002

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_841