maximin 5

General Information


DCTPep ID  DCTPep00018

Peptide Name   maximin 5

Sequence  SIGAKILGGVKTFFKGALKELASTYLQ

Sequence Length  27

UniProt ID  P83084  Q58T60  Q58T61  C3RSZ0  C3RST5  C3RST4  B5L156  C3RSY9  C3RTJ4  C3RTL1  B5L129 

PubChem CID  Not available

Origin  Bombina maxima

Type  Native peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
C8166 Adult T acute lymphoblastic leukemia IC50=34.4 µg/ml MTT assay 48 h 1
BIU-87 Bladder carcinoma IC50>50 µg/ml MTT assay 48 h 1
Molt-4 Adult T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia IC50>50 µg/ml MTT assay 48 h 1
T24 Bladder carcinoma IC50>50 µg/ml MTT assay 48 h 1

Hemolytic Activity  Had little hemolytic activity to red blood cells even with the concentration of the peptides up to 50 μg/ml

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00018

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C133H218N32O36

Absent amino acids  CDHMNPRW

Theoretical pI  9.82

Acidic residues  1

Basic residues  4

Polar residues  9

Molecular weight (Average)  2841.39

Molecular weight (Monoisotopic)  2839.62

Common amino acids  GKL

Net charge  3

Instability index (II)  15.62

Aliphatic index  108.52

Grand average of hydropathicity (GRAVY)  0.404

Half Life 
  1.9 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 1490
  Abs 0.1% (=1 g/l) 0.524

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 11835991

Title  Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima

Doi 10.1016/s0196-9781(01)00641-6

Year 

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPR_843

DCTPep is developed by Dr.Zheng's team.