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maximin 5
General Information
DCTPep ID DCTPep00018
Peptide Name maximin 5
Sequence SIGAKILGGVKTFFKGALKELASTYLQ
Sequence Length 27
UniProt ID P83084 Q58T60 Q58T61 C3RSZ0 C3RST5 C3RST4 B5L156 C3RSY9 C3RTJ4 C3RTL1 B5L129
PubChem CID Not available
Origin Bombina maxima
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| C8166 | Adult T acute lymphoblastic leukemia | IC50=34.4 µg/ml | MTT assay | 48 h | 1 |
| BIU-87 | Bladder carcinoma | IC50>50 µg/ml | MTT assay | 48 h | 1 |
| Molt-4 | Adult T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | IC50>50 µg/ml | MTT assay | 48 h | 1 |
| T24 | Bladder carcinoma | IC50>50 µg/ml | MTT assay | 48 h | 1 |
Hemolytic Activity Had little hemolytic activity to red blood cells even with the concentration of the peptides up to 50 μg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00018
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C133H218N32O36
Absent amino acids CDHMNPRW
Theoretical pI 9.82
Acidic residues 1
Basic residues 4
Polar residues 9
Molecular weight (Average) 2841.39
Molecular weight (Monoisotopic) 2839.62
Common amino acids GKL
Net charge 3
Instability index (II) 15.62
Aliphatic index 108.52
Grand average of hydropathicity (GRAVY) 0.404
Half Life
1.9 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.524
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 11835991
Title Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima
Doi 10.1016/s0196-9781(01)00641-6
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_843
This work is licensed under a Creative Commons Attribution 4.0 International License.