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novispirin G-10
General Information
DCTPep ID DCTPep00019
Peptide Name novispirin G-10
Sequence KNLRRIIRKGIHIIKKYG
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | 33.2% Cytotoxicity=200 µg/ml | MTT assay | 20h | 1 |
| ME-180 | Human papillomavirus-related cervical squamous cell carcinoma; Squamous cell carcinoma of the cervix uteri | 33.2% Cytotoxicity=200 µg/ml | MTT assay | 20h | 1 |
Hemolytic Activity Human erythrocytes: 3% Hemolysis=80 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 1HU6
Predicted Structure DCTPep00019
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C101H180N34O21
Absent amino acids ACDEFMPQSTVW
Theoretical pI 11.75
Acidic residues 0
Basic residues 8
Polar residues 4
Molecular weight (Average) 2206.76
Molecular weight (Monoisotopic) 2205.41
Common amino acids I
Net charge 8
Instability index (II) 64.37
Aliphatic index 130.00
Grand average of hydropathicity (GRAVY) -0.644
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.675
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 11932493
Title Impact of single-residue mutations on the structure and function of ovispirin/novispirin antimicrobial peptides
Year 2002
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_696
This work is licensed under a Creative Commons Attribution 4.0 International License.