This work is licensed under a Creative Commons Attribution 4.0 International License.
Alloferon 2
General Information
DCTPep ID DCTPep00051
Peptide Name Alloferon 2
Sequence GVSGHGQHGVHG
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin the blow fly Calliphora vicina (Diptera)
Type Native peptide
Classification
ACP Tumor active peptide Immune system stimulating peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | lower doses of cancer cells could be eliminated after administration of 25 μg of alloferon | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism (i) stimulates natural cytotoxicity of human peripheral blood lymphocytes, (ii) induces IFN synthesis in mouse and human models, and (iii) enhances antiviral and antitumor resistance in mice.
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C46H69N19O15
Absent amino acids ACDEFIKLMNPRTWY
Theoretical pI 7.02
Acidic residues 0
Basic residues 3
Polar residues 6
Molecular weight (Average) 1128.17
Molecular weight (Monoisotopic) 1127.52
Common amino acids G
Net charge 3
Instability index (II) -16.76
Aliphatic index 48.33
Grand average of hydropathicity (GRAVY) -0.625
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12235362
Title Antiviral and antitumor peptides from insects
Year 2002
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.