L8
General Information
DCTPep ID DCTPep00060
Peptide Name L8
Sequence PAWAKAFRAAARMKLKAA
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane-targeted
Activity Information
Cell Line | Disease | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|
Meth A | Mouse fibrosarcoma | IC50=110 µM | MTT assay | 4 h | 1 |
HT-29 | Colon adenocarcinoma | IC50=180 µM | MTT assay | 4 h | 1 |
MT-1 | Human mammary carcinoma | IC50=87 µM | MTT assay | 4 h | 1 |
Hemolytic Activity Human red blood cells: EC50>489 µM
Normal (non-cancerous) Cytotoxicity Fibroblas: IC50>489 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00060
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C90H148N28O19S1
Absent amino acids CDEGHINQSTVY
Theoretical pI 12.02
Acidic residues 0
Basic residues 5
Polar residues 0
Molecular weight (Average) 1958.4
Molecular weight (Monoisotopic) 1957.12
Common amino acids A
Net charge 5
Instability index (II) 2.36
Aliphatic index 66.11
Grand average of hydropathicity (GRAVY) -0.017
Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.808
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12366526
Title Enhanced antitumor activity and selectivity of lactoferrin-derived peptides
Doi 10.1034/j.1399-3011.2002.21008.x
Year 2002
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available