L10

General Information


DCTPep ID  DCTPep00062

Peptide Name   L10

Sequence  PAARKAFRWAWRMLKKAA

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Membrane-targeted



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MT-1 Human mammary carcinoma IC50=20 µM MTT assay 4 h 1
Meth A Mouse fibrosarcoma IC50=24 µM MTT assay 4 h 1
HT-29 Colon adenocarcinoma IC50=35 µM MTT assay 4 h 1

Hemolytic Activity  Human red blood cells: EC50>463 µM

Normal (non-cancerous) Cytotoxicity  Fibroblas: IC50=190 µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00062

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C101H160N32O19S1

Absent amino acids  CDEGHINQSTVY

Theoretical pI  12.31

Acidic residues  0

Basic residues  6

Polar residues  0

Molecular weight (Average)  2158.64

Molecular weight (Monoisotopic)  2157.23

Common amino acids  A

Net charge  6

Instability index (II)  38.9

Aliphatic index  55.00

Grand average of hydropathicity (GRAVY)  -0.517

Half Life 
  >20 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  ? (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 11000
  Abs 0.1% (=1 g/l) 5.096

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 12366526

Title  Enhanced antitumor activity and selectivity of lactoferrin-derived peptides

Doi 10.1034/j.1399-3011.2002.21008.x

Year  2002

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.