Peptide Libraray

L13

General Information

DCTPep ID DCTPep00065

Peptide Name L13

Sequence PAWRKAFRKAWRMLKKAA

Sequence Length 18

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane-targeted

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MT-1	Human mammary carcinoma	IC50=12 µM	MTT assay	4 h	1
Meth A	Mouse fibrosarcoma	IC50=14 µM	MTT assay	4 h	1
HT-29	Colon adenocarcinoma	IC50=29 µM	MTT assay	4 h	1

Hemolytic Activity Human red blood cells: EC50>451 µM

Normal (non-cancerous) Cytotoxicity Fibroblas: IC50=59 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00065

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C104H167N33O19S1

Absent amino acids CDEGHINQSTVY

Theoretical pI 12.31

Acidic residues 0

Basic residues 7

Polar residues 0

Molecular weight (Average) 2215.74

Molecular weight (Monoisotopic) 2214.28

Common amino acids A

Net charge 7

Instability index (II) 15.43

Aliphatic index 49.44

Grand average of hydropathicity (GRAVY) -0.833

Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 4.964

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 12366526

Title Enhanced antitumor activity and selectivity of lactoferrin-derived peptides

Doi 10.1034/j.1399-3011.2002.21008.x

Year 2002

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available