Peptide Libraray

L14

General Information

DCTPep ID DCTPep00066

Peptide Name L14

Sequence PAWRKARRWAWRMKKLAA

Sequence Length 18

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane-targeted

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Meth A	Mouse fibrosarcoma	IC50=125 µM	MTT assay	4 h	1
MT-1	Human mammary carcinoma	IC50=141 µM	MTT assay	4 h	1
HT-29	Colon adenocarcinoma	IC50=423 µM	MTT assay	4 h	1

Hemolytic Activity Human red blood cells: EC50>438 µM

Normal (non-cancerous) Cytotoxicity Fibroblas: IC50>438 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00066

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C106H168N36O19S1

Absent amino acids CDEFGHINQSTVY

Theoretical pI 12.48

Acidic residues 0

Basic residues 7

Polar residues 0

Molecular weight (Average) 2282.79

Molecular weight (Monoisotopic) 2281.3

Common amino acids A

Net charge 7

Instability index (II) 70.72

Aliphatic index 49.44

Grand average of hydropathicity (GRAVY) -1.072

Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 16500
Abs 0.1% (=1 g/l) 7.228

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 12366526

Title Enhanced antitumor activity and selectivity of lactoferrin-derived peptides

Doi 10.1034/j.1399-3011.2002.21008.x

Year 2002

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available