Peptide Libraray

MG2d

General Information

DCTPep ID DCTPep00068

Peptide Name MG2d

Sequence GIGKFLHSAKKWGKAFVGQIMNC

Sequence Length 23

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane-targeted

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	30-40% viablity=100 µM	MTT assay	24 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00068

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C116H182N32O27S2

Absent amino acids DEPRTY

Theoretical pI 10.04

Acidic residues 0

Basic residues 5

Polar residues 7

Molecular weight (Average) 2521.04

Molecular weight (Monoisotopic) 2519.33

Common amino acids GK

Net charge 5

Instability index (II) -10.96

Aliphatic index 72.17

Grand average of hydropathicity (GRAVY) 0.065

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.182, assuming all pairs of Cys residues form cystines
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.182, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 12417587

Title Translocation of analogues of the antimicrobial peptides magainin and buforin across human cell membranes

Doi 10.1074/jbc.M208762200

Year 2003

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available