Citropin 16

General Information


DCTPep ID  DCTPep00086

Peptide Name   Citropin 16

Sequence  GLFAVIKKVASVIKKL

Sequence Length  16

UniProt ID  Not available

PubChem CID  Not available

Origin  Amphibian skin secretions

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Membrane-targeted



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
Breast cancer group (NCI) Breast Carcinoma IC50=10 μM Not available Not available 1
CNS cancer group (NCI) CNS Carcinoma IC50=10 μM Not available Not available 1
Colon cancer group (NCI) Colon Carcinoma IC50=10 μM Not available Not available 1
Leukemia group (NCI) Leukemia IC50=10 μM Not available Not available 1
Lung cancer group (NCI) Lung Carcinoma IC50=10 μM Not available Not available 1
Melanoma cancer group (NCI) Melanoma cancer group (NCI) IC50=10 μM Not available Not available 1
Ovarian cancer group (NCI) Ovarian Carcinoma IC50=10 μM Not available Not available 1
Prostate cancer group (NCI) Prostate Carcinoma IC50=10 μM Not available Not available 1
Renal cancer group (NCI) Renal Carcinoma IC50=10 μM Not available Not available 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00086

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C83H148N20O18

Absent amino acids  CDEHMNPQRTWY

Theoretical pI  10.48

Acidic residues  0

Basic residues  4

Polar residues  2

Molecular weight (Average)  1714.21

Molecular weight (Monoisotopic)  1713.13

Common amino acids  K

Net charge  4

Instability index (II)  -11.85

Aliphatic index  164.37

Grand average of hydropathicity (GRAVY)  1.175

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 12631273

Title  nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications

Doi 10.1046/j.1432-1033.2003.03462.x

Year  2003

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.