This work is licensed under a Creative Commons Attribution 4.0 International License.
l3,4,8,10K5L7
General Information
DCTPep ID DCTPep00093
Peptide Name l3,4,8,10K5L7
Sequence KLllKLKlKlLK
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Diastereomeric peptide
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| B16-F10 | Mouse melanoma | LC50=100 µM | XTT assay | 24h | 1 |
| D122 | Malignant tumors of the mouse pulmonary system | LC50>50 µM | XTT assay | 24h | 1 |
Hemolytic Activity Human erythrocyte: Hemolysis% at 50 μm peptide LC50=0 µM
Normal (non-cancerous) Cytotoxicity NIH-3T3: LC50>100 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification l=D-Leucine; k=D-Lysine
Chiral Mix
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12646578
Title Designed antimicrobial and antitumor peptides with high selectivity
Year 2003
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.