Peptide Libraray

MRP

General Information

DCTPep ID DCTPep00095

Peptide Name MRP

Sequence AIGSILGALAKGLPTLISWIKNR

Sequence Length 23

UniProt ID Not available

PubChem CID Not available

Origin Rana tagoi

Type Native peptide

Classification

ACP Tumor active peptide Membrane-targeted

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
EL4 T-lymphoma	T-cell lymphoma	LC50=14 μM	Trypan blue assay	1 h	1

Hemolytic Activity Human erythrocytes: HC50=8 μM

Normal (non-cancerous) Cytotoxicity L929: LC50=20 μM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00095

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C111H190N30O28

Absent amino acids CDEFHMQVY

Theoretical pI 11.17

Acidic residues 0

Basic residues 3

Polar residues 7

Molecular weight (Average) 2392.91

Molecular weight (Monoisotopic) 2391.44

Common amino acids IL

Net charge 3

Instability index (II) 15.24

Aliphatic index 148.70

Grand average of hydropathicity (GRAVY) 0.730

Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.298

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 12804591

Title A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties

Doi 10.1016/s0006-291x(03)00999-9

Year 2003

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available