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PTP2
General Information
DCTPep ID DCTPep00100
Peptide Name PTP2
Sequence FAGLAANFLPTIICKISYKC
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Induce apoptosis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | IC50>100 µg/ml | MTT assay | 96 h | 1 |
| Hep 3B | Childhood hepatocellular carcinoma; Pediatric hepatocellular carcinoma | IC50>100 µg/ml | MTT assay | 96 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50>100 µg/ml | MTT assay | 96 h | 1 |
| PC-3 | Prostate carcinoma | IC50>100 µg/ml | MTT assay | 96 h | 1 |
Hemolytic Activity Human RBCs: less than 6% hemolysis at 100 μg/ml
Normal (non-cancerous) Cytotoxicity HEK293: IC50>100 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00100
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys14<--->Cys20
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C102H161N23O25S2
Absent amino acids DEHMQRVW
Theoretical pI 8.86
Acidic residues 0
Basic residues 2
Polar residues 7
Molecular weight (Average) 2173.66
Molecular weight (Monoisotopic) 2172.15
Common amino acids AI
Net charge 2
Instability index (II) 7.37
Aliphatic index 112.50
Grand average of hydropathicity (GRAVY) 1.050
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1615
Abs 0.1% (=1 g/l) 0.743, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.685, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 14499271
Title In vitro activities of native and designed peptide antibiotics against drug sensitive and resistant tumor cell lines
Doi 10.1016/s0196-9781(03)00194-3
Year 2003
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.