PTP6

General Information


DCTPep ID  DCTPep00103

Peptide Name   PTP6

Sequence  FLKLLKKLAAKFL

Sequence Length  13

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Induce apoptosis



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
PC-3 Prostate carcinoma IC50=13.27 ± 4.27 µg/ml MTT assay 96 h 1
A549 Lung adenocarcinoma IC50=13.94 ± 3.96 µg/ml MTT assay 96 h 1
Hep 3B Childhood hepatocellular carcinoma; Pediatric hepatocellular carcinoma IC50=15.07 ± 1.59 µg/ml MTT assay 96 h 1
MCF-7 Invasive breast carcinoma of no special type IC50=17.56 ± 6.23 µg/ml MTT assay 96 h 1

Hemolytic Activity  Human RBCs: less than 6% hemolysis at 100 μg/ml

Normal (non-cancerous) Cytotoxicity  HEK293: IC50=14.00 ± 1.46 µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00103

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C78H133N17O14

Absent amino acids  CDEGHIMNPQRSTVWY

Theoretical pI  10.48

Acidic residues  0

Basic residues  4

Polar residues  0

Molecular weight (Average)  1533.02

Molecular weight (Monoisotopic)  1532.02

Common amino acids  L

Net charge  4

Instability index (II)  -16.89

Aliphatic index  165.38

Grand average of hydropathicity (GRAVY)  0.969

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 14499271

Title  In vitro activities of native and designed peptide antibiotics against drug sensitive and resistant tumor cell lines

Doi 10.1016/s0196-9781(03)00194-3

Year  2003

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




CancerPPD ID  1006

CancerPPD ID  1014

CancerPPD ID  1022

CancerPPD ID  1030

CancerPPD ID  1038

DCTPep is developed by Dr.Zheng's team.