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PTP7
General Information
DCTPep ID DCTPep00104
Peptide Name PTP7
Sequence FLGALFKALSKLL
Sequence Length 13
UniProt ID P80399
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane lysis Induce apoptosis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| PANC-1 | Pancreatic ductal adenocarcinoma | IC50=11 μM | MTT assay | 2 h | 2 |
| PC-3 | Prostate carcinoma | IC50=5.01±0.42 µg/ml | MTT assay | 96 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=5.25±0.63 µg/ml | MTT assay | 96 h | 1 |
| Hep 3B | Childhood hepatocellular carcinoma; Pediatric hepatocellular carcinoma | IC50=5.40 ± 0.91 µg/ml | MTT assay | 96 h | 1 |
| A549 | Lung adenocarcinoma | IC50=8.01 ± 1.32 µg/ml | MTT assay | 96 h | 1 |
Hemolytic Activity Human RBCs: less than 6% hemolysis at 100 μg/ml
Normal (non-cancerous) Cytotoxicity HEK293: IC50=6.71 ± 0.47 µg/ml; MCF-10A: IC50=8 μM
Target Not available
Affinity Not available
Mechanism Induce cell death via apoptosis
Structure Information
PDB ID Not available
Predicted Structure DCTPep00104
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C71H117N15O15
Absent amino acids CDEHIMNPQRTVWY
Theoretical pI 10.00
Acidic residues 0
Basic residues 2
Polar residues 2
Molecular weight (Average) 1420.8
Molecular weight (Monoisotopic) 1419.89
Common amino acids L
Net charge 2
Instability index (II) -15.39
Aliphatic index 165.38
Grand average of hydropathicity (GRAVY) 1.477
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 14499271
Title In vitro activities of native and designed peptide antibiotics against drug sensitive and resistant tumor cell lines
Doi 10.1016/s0196-9781(03)00194-3
Year 2003
Literature 2
Pubmed ID 22526264
Title Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
This work is licensed under a Creative Commons Attribution 4.0 International License.