Peptide Libraray

Gymnin

General Information

DCTPep ID DCTPep00106

Peptide Name Gymnin

Sequence KTCENLADDY

Sequence Length 10

UniProt ID Not available

PubChem CID Not available

Origin Gymnocladus chinensis

Type Native peptide

Classification

ACP Tumor active peptide Affect cell cycle

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HepG2	Hepatoblastoma	37±4% Reduction in viability=50.0 µM	MTT assay	72h	1
L1210	Mouse leukemia	40±3% Reduction in viability=50.0 µM	MTT assay	72h	1
M1	Mouse myeloid leukemia	49±3% Reduction in viability=50.0 µM	MTT assay	72h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C48H74N12O20S1

Absent amino acids FGHIMPQRSVW

Theoretical pI 4.03

Acidic residues 3

Basic residues 1

Polar residues 4

Molecular weight (Average) 1171.24

Molecular weight (Monoisotopic) 1170.49

Common amino acids D

Net charge -2

Instability index (II) 0.51

Aliphatic index 49.00

Grand average of hydropathicity (GRAVY) -1.180

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.272, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.272, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 14499273

Title Gymnin, a potent defensin-like antifungal peptide from the Yunnan bean (Gymnocladus chinensis Baill)

Doi 10.1016/s0196-9781(03)00192-x

Year 2003

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available