This work is licensed under a Creative Commons Attribution 4.0 International License.
p369–377
General Information
DCTPep ID DCTPep00107
Peptide Name p369–377
Sequence KIFGSLAFL
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Immune system stimulating peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| N202.A2 | Spontaneous tumor in A2×neu mice | Animals immunized three times with DC pulsed with p369–377 or p773–782 peptide showed ~25–30% tumor growth inhibition, while two immunizations induced ~12–15% tumor growth inhibition and one injection | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C50H78N10O11
Absent amino acids CDEHMNPQRTVWY
Theoretical pI 8.75
Acidic residues 0
Basic residues 1
Polar residues 2
Molecular weight (Average) 995.23
Molecular weight (Monoisotopic) 994.59
Common amino acids FL
Net charge 1
Instability index (II) -0.54
Aliphatic index 141.11
Grand average of hydropathicity (GRAVY) 1.600
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 14991605
Title The CD8+ T cell repertoire against Her-2/neu antigens in neu transgenic mice is of low avidity with antitumor activity
Year 2004
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.