This work is licensed under a Creative Commons Attribution 4.0 International License.
p773–782
General Information
DCTPep ID DCTPep00108
Peptide Name p773–782
Sequence VMAGVGSPYV
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Immune system stimulating peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| N202.A2 | Spontaneous tumor in A2×neu mice | Animals immunized three times with DC pulsed with p369–377 or p773–782 peptide showed ~25–30% tumor growth inhibition, while two immunizations induced ~12–15% tumor growth inhibition and one injection | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism The low-avidity T cell repertoire for a self tumor antigen is functional, can be activated and expanded with the help of costimulation
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C44H70N10O13S1
Absent amino acids CDEFHIKLNQRTW
Theoretical pI 5.49
Acidic residues 0
Basic residues 0
Polar residues 4
Molecular weight (Average) 979.16
Molecular weight (Monoisotopic) 978.48
Common amino acids V
Net charge 0
Instability index (II) 56.79
Aliphatic index 97.00
Grand average of hydropathicity (GRAVY) 1.180
Half Life
100 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.522
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 14991605
Title The CD8+ T cell repertoire against Her-2/neu antigens in neu transgenic mice is of low avidity with antitumor activity
Year 2004
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.