Peptide Libraray

P. sajor-caju Rnase

General Information

DCTPep ID DCTPep00109

Peptide Name P. sajor-caju Rnase

Sequence DNGEAGRAAR

Sequence Length 10

UniProt ID Not available

PubChem CID Not available

Origin Pleurotus sajor-caju

Type Native peptide

Classification

ACP Tumor active peptide Affect cell cycle

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
L1210	Mouse leukemia	IC50=0.1 µM	MTT assay	48h	1
HepG2	Hepatoblastoma	IC50=0.2 µM	MTT assay	48h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Mouse splenocytes: IC50=0.065 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C38H65N17O16

Absent amino acids CFHIKLMPQSTVWY

Theoretical pI 6.07

Acidic residues 2

Basic residues 2

Polar residues 3

Molecular weight (Average) 1016.04

Molecular weight (Monoisotopic) 1015.48

Common amino acids A

Net charge 0

Instability index (II) -13.57

Aliphatic index 30.00

Grand average of hydropathicity (GRAVY) -1.490

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 15003351

Title A ribonuclease with antimicrobial, antimitogenic and antiproliferative activities from the edible mushroom Pleurotus sajor-caju

Doi 10.1016/j.peptides.2003.11.012

Year 2004

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available