Peptide Libraray

HCAP18(109-135)

General Information

DCTPep ID DCTPep00110

Peptide Name HCAP18(109-135)

Sequence FRKSKEKIGKEFKRIVQRIKDFLRNLV

Sequence Length 27

UniProt ID Q1KLX1 P49913

PubChem CID Not available

Origin hCAP18 Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Induce apoptosis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
SAS-H1	Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue	88 ± 7.2% cytotoxicity=40 mg/ml	Trypan blue assay	24-96 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00110

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C155H263N47O37

Absent amino acids ACHMPTWY

Theoretical pI 11.10

Acidic residues 3

Basic residues 10

Polar residues 3

Molecular weight (Average) 3377.09

Molecular weight (Monoisotopic) 3375.01

Common amino acids K

Net charge 7

Instability index (II) 12.47

Aliphatic index 93.70

Grand average of hydropathicity (GRAVY) -0.822

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 15279899

Title C-terminal domain of human CAP18 antimicrobial peptide induces apoptosis in oral squamous cell carcinoma SAS-H1 cells

Doi 10.1016/j.canlet.2004.04.006

Year 2004

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available