Peptide Libraray

Ac-(HHPHG)4 -NH2

General Information

DCTPep ID DCTPep00111

Peptide Name Ac-(HHPHG)4 -NH2

Sequence HHPHGHHPHGHHPHGHHPHG

Sequence Length 20

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Cancer targeted peptides Antiangiogenic

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
3LL	Lewis lung carcinoma	The 50 mg/kg dose in the 3LL model significantly inhibited tumor growth by 48%	Syngeneic tumor models	Not available	1
B16-F1	Mouse melanoma	The 50 mg/kg dose in the 3LL model significantly inhibited tumor growth by 48%	Syngeneic tumor models	Not available	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Tropomyosin

Affinity Not available

Mechanism Bind to Tropomyosin and Have Antiangiogenic and Antitumor Activities

Structure Information

PDB ID Not available

Predicted Structure DCTPep00111

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Acetylation

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C100H126N44O21

Absent amino acids ACDEFIKLMNQRSTVWY

Theoretical pI 7.40

Acidic residues 0

Basic residues 12

Polar residues 4

Molecular weight (Average) 2280.38

Molecular weight (Monoisotopic) 2279.01

Common amino acids H

Net charge 12

Instability index (II) -17

Aliphatic index 0.00

Grand average of hydropathicity (GRAVY) -2.320

Half Life
3.5 hours (mammalian reticulocytes, in vitro).
10 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 15313924

Title Peptides derived from the histidine-proline domain of the histidine-proline-rich glycoprotein bind to tropomyosin and have antiangiogenic and antitumor activities

Doi 10.1158/0008-5472.CAN-04-0440

Year 2004

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available