Peptide Libraray

Coccinin

General Information

DCTPep ID DCTPep00121

Peptide Name Coccinin

Sequence KQTENLADTY

Sequence Length 10

UniProt ID Not available

PubChem CID Not available

Origin Phaseolus coccineus

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HL-60	Adult acute myeloid leukemia; Acute myeloid leukemia	IC50=30 µM	MTT assay	72 h	1
L1210	Adult acute myeloid leukemia; Acute myeloid leukemia	IC50=40 µM	MTT assay	72 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C50H79N13O20

Absent amino acids CFGHIMPRSVW

Theoretical pI 4.37

Acidic residues 2

Basic residues 1

Polar residues 4

Molecular weight (Average) 1182.25

Molecular weight (Monoisotopic) 1181.56

Common amino acids T

Net charge -1

Instability index (II) 28.42

Aliphatic index 49.00

Grand average of hydropathicity (GRAVY) -1.500

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.260

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 15572193

Title Coccinin, an antifungal peptide with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from large scarlet runner beans

Doi 10.1016/j.peptides.2004.08.003

Year 2004

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available