Peptide Libraray

Agrocybin

General Information

DCTPep ID DCTPep00122

Peptide Name Agrocybin

Sequence ANDPQCLYGNVAAKF

Sequence Length 15

UniProt ID Not available

PubChem CID Not available

Origin Agrocybe cylindracea

Type Native peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HepG2	Hepatoblastoma	Not active up to 110 µM	Radioactive precursor assay	48 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00122

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C71H107N19O22S1

Absent amino acids EHIMRSTW

Theoretical pI 5.87

Acidic residues 1

Basic residues 1

Polar residues 5

Molecular weight (Average) 1610.8

Molecular weight (Monoisotopic) 1609.76

Common amino acids A

Net charge 0

Instability index (II) 18.67

Aliphatic index 65.33

Grand average of hydropathicity (GRAVY) -0.167

Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.925, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.925, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 15629530

Title Agrocybin, an antifungal peptide from the edible mushroom Agrocybe cylindracea

Doi 10.1016/j.peptides.2004.09.011

Year 2005

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available