hP2

General Information


DCTPep ID  DCTPep00127

Peptide Name   hP2

Sequence  MRGIRGADFQAFQQARAVGLAGTFR

Sequence Length  25

UniProt ID  Not available

PubChem CID  Not available

Origin  Human endostatin peptides

Type  Native peptide

Classification

  

Cancer targeted peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
BxPC-3 Pancreatic ductal adenocarcinoma 19% inhibition at 7 mg/kg/d Matrigel Assay 672 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  α5β1 integrin, metalloproteinases

Affinity  Not available

Mechanism  Inhibition of endothelial cell proliferation, migration, and tube formation



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00127

(Please note that there is the predicted structure, predicted by AlphaFold)

SequenceNo structure available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C119H190N40O32S1

Absent amino acids  CEHKNPSWY

Theoretical pI  12.00

Acidic residues  1

Basic residues  4

Polar residues  5

Molecular weight (Average)  2725.13

Molecular weight (Monoisotopic)  2723.42

Common amino acids  A

Net charge  3

Instability index (II)  -7.56

Aliphatic index  62.80

Grand average of hydropathicity (GRAVY)  -0.100

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 15867360

Title  A 27-amino-acid synthetic peptide corresponding to the NH2-terminal zinc-binding domain of endostatin is responsible for its antitumor activity

Doi 10.1158/0008-5472.CAN-04-1833

Year  2005

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.