hP2
General Information
DCTPep ID DCTPep00127
Peptide Name hP2
Sequence MRGIRGADFQAFQQARAVGLAGTFR
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Human endostatin peptides
Type Native peptide
Classification
Cancer targeted peptides
Activity Information
Cell Line | Disease | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|
BxPC-3 | Pancreatic ductal adenocarcinoma | 19% inhibition at 7 mg/kg/d | Matrigel Assay | 672 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target α5β1 integrin, metalloproteinases
Affinity Not available
Mechanism Inhibition of endothelial cell proliferation, migration, and tube formation
Structure Information
PDB ID Not available
Predicted Structure DCTPep00127
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C119H190N40O32S1
Absent amino acids CEHKNPSWY
Theoretical pI 12.00
Acidic residues 1
Basic residues 4
Polar residues 5
Molecular weight (Average) 2725.13
Molecular weight (Monoisotopic) 2723.42
Common amino acids A
Net charge 3
Instability index (II) -7.56
Aliphatic index 62.80
Grand average of hydropathicity (GRAVY) -0.100
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 15867360
Title A 27-amino-acid synthetic peptide corresponding to the NH2-terminal zinc-binding domain of endostatin is responsible for its antitumor activity
Doi 10.1158/0008-5472.CAN-04-1833
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available