Peptide Libraray

hP3

General Information

DCTPep ID DCTPep00128

Peptide Name hP3

Sequence TFRAFLSSRLQDLYSIVRRADRAAV

Sequence Length 25

UniProt ID P39060

PubChem CID Not available

Origin Human endostatin peptides

Type Native peptide

Classification

Cancer targeted peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
BxPC-3	Pancreatic ductal adenocarcinoma	No inhibition at 7 mg/kg/d	Matrigel Assay	672 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target α5β1 integrin, metalloproteinases

Affinity Not available

Mechanism Inhibition of endothelial cell proliferation, migration, and tube formation

Structure Information

PDB ID Not available

Predicted Structure DCTPep00128

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C129H211N41O36

Absent amino acids CEGHKMNPW

Theoretical pI 11.42

Acidic residues 2

Basic residues 5

Polar residues 5

Molecular weight (Average) 2912.35

Molecular weight (Monoisotopic) 2910.59

Common amino acids R

Net charge 3

Instability index (II) 63.79

Aliphatic index 101.60

Grand average of hydropathicity (GRAVY) -0.012

Half Life
7.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.512

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 15867360

Title A 27-amino-acid synthetic peptide corresponding to the NH2-terminal zinc-binding domain of endostatin is responsible for its antitumor activity

Doi 10.1158/0008-5472.CAN-04-1833

Year 2005

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available