Peptide Libraray

hP5

General Information

DCTPep ID DCTPep00130

Peptide Name hP5

Sequence GSEGPLKPGARIFSFDGKDVLRHPT

Sequence Length 25

UniProt ID P39060

PubChem CID Not available

Origin Human endostatin peptides

Type Native peptide

Classification

ACP Tumor active peptide Cancer targeted peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
BxPC-3	Pancreatic ductal adenocarcinoma	29% inhibition at 7 mg/kg/d	Matrigel Assay	672 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target α5β1 integrin, metalloproteinases

Affinity Not available

Mechanism Inhibition of endothelial cell proliferation, migration, and tube formation

Structure Information

PDB ID Not available

Predicted Structure DCTPep00130

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C120H189N35O35

Absent amino acids CMNQWY

Theoretical pI 8.60

Acidic residues 3

Basic residues 5

Polar residues 7

Molecular weight (Average) 2682.03

Molecular weight (Monoisotopic) 2680.41

Common amino acids G

Net charge 2

Instability index (II) 23.29

Aliphatic index 62.40

Grand average of hydropathicity (GRAVY) -0.620

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 15867360

Title A 27-amino-acid synthetic peptide corresponding to the NH2-terminal zinc-binding domain of endostatin is responsible for its antitumor activity

Doi 10.1158/0008-5472.CAN-04-1833

Year 2005

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available