Peptide Libraray

hP6

General Information

DCTPep ID DCTPep00131

Peptide Name hP6

Sequence HPTWPQKSVWHGSDPNGRRLTESY

Sequence Length 24

UniProt ID P39060

PubChem CID Not available

Origin Human endostatin peptides

Type Native peptide

Classification

Cancer targeted peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
BxPC-3	Pancreatic ductal adenocarcinoma	No inhibition at 7 mg/kg/d	Matrigel Assay	672 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target α5β1 integrin, metalloproteinases

Affinity Not available

Mechanism Inhibition of endothelial cell proliferation, migration, and tube formation

Structure Information

PDB ID Not available

Predicted Structure DCTPep00131

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C126H183N39O37

Absent amino acids ACFIM

Theoretical pI 8.60

Acidic residues 2

Basic residues 5

Polar residues 9

Molecular weight (Average) 2836.08

Molecular weight (Monoisotopic) 2834.36

Common amino acids PS

Net charge 3

Instability index (II) 49.35

Aliphatic index 28.33

Grand average of hydropathicity (GRAVY) -1.575

Half Life
3.5 hours (mammalian reticulocytes, in vitro).
10 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 12490
Abs 0.1% (=1 g/l) 4.404

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 15867360

Title A 27-amino-acid synthetic peptide corresponding to the NH2-terminal zinc-binding domain of endostatin is responsible for its antitumor activity

Doi 10.1158/0008-5472.CAN-04-1833

Year 2005

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available