hP7

General Information


DCTPep ID  DCTPep00132

Peptide Name   hP7

Sequence  ETWRTEAPSATGQASSLLGGRLLGQ

Sequence Length  25

UniProt ID  P39060 

PubChem CID  Not available

Origin  Human endostatin peptides

Type  Native peptide

Classification

  

Cancer targeted peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
BxPC-3 Pancreatic ductal adenocarcinoma No inhibition at 7 mg/kg/d Matrigel Assay 672 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  α5β1 integrin, metalloproteinases

Affinity  Not available

Mechanism  Inhibition of endothelial cell proliferation, migration, and tube formation



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00132

(Please note that there is the predicted structure, predicted by AlphaFold)

SequenceNo structure available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C110H180N34O38

Absent amino acids  CDFHIKMNVY

Theoretical pI  6.24

Acidic residues  2

Basic residues  2

Polar residues  10

Molecular weight (Average)  2586.84

Molecular weight (Monoisotopic)  2585.32

Common amino acids  GL

Net charge  0

Instability index (II)  35.94

Aliphatic index  74.40

Grand average of hydropathicity (GRAVY)  -0.440

Half Life 
  1 hours (mammalian reticulocytes, in vitro).
  30 min (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 2.126

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 15867360

Title  A 27-amino-acid synthetic peptide corresponding to the NH2-terminal zinc-binding domain of endostatin is responsible for its antitumor activity

Doi 10.1158/0008-5472.CAN-04-1833

Year  2005

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.