Peptide Libraray

Laxaphycin B

General Information

DCTPep ID DCTPep00134

Peptide Name Laxaphycin B

Sequence AXQNXXXPLXXVX

Sequence Length 13

UniProt ID Not available

PubChem CID 457000

Origin Terrestrial blue-green alga Anabaena laxa or the marine cyanobacterium Lyngbya Majuscula

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
CEM/VM-1	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	40% inhibition at 1 µM	Cell Viability assay	96 h	1
CEM-VLB	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	40% inhibition at 1 µM	Cell Viability assay	96 h	1
CEM-WT	human lymphoblastic cancer	40% inhibition at 1 µM	Cell Viability assay	96 h	1
CEM/VM-1	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	44% inhibition at 1 µM	Cell Viability assay	96 h	1
CEM-VLB	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	44% inhibition at 1 µM	Cell Viability assay	96 h	1
CEM-WT	human lymphoblastic cancer	44% inhibition at 1 µM	Cell Viability assay	96 h	1
CEM-WT	human lymphoblastic cancer	50% inhibition at 1 µM	Cell Viability assay	96 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond X1<--->X13

N-terminal Modification None

C-terminal Modification None

Other Modification X(2/13)=Leu(3-OH); X(5)=N(Me)xiIle; X(6)=Asn(3-OH); X(7/10)=xiThr; X(11)=Unk

Chiral L

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 15875779

Title Cytotoxic effect of Laxaphycins A and B on human lymphoblastic cells (CCRF-CEM) using digitised videomicrofluorometry

Doi Not available

Year 2005

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available