This work is licensed under a Creative Commons Attribution 4.0 International License.
Laxaphycin A
General Information
DCTPep ID DCTPep00135
Peptide Name Laxaphycin A
Sequence XXXFLXXLGXX
Sequence Length 11
UniProt ID Not available
PubChem CID 6473981
Origin Terrestrial blue-green alga Anabaena laxa or the marine cyanobacterium Lyngbya Majuscula
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| CEM/VM-1 | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | No inhibition at 4 µM | Cell Viability assay | 96 h | 1 |
| CEM-VLB | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | No inhibition at 4 µM | Cell Viability assay | 96 h | 1 |
| CEM-WT | human lymphoblastic cancer | No inhibition at 4 µM | Cell Viability assay | 96 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond X1<--->X11
N-terminal Modification None
C-terminal Modification None
Other Modification X(1)=Abu(2,3-dehydro); X(2)=xiHyp; X(3/11)=Hse; X(6/7)=xiIle; X(10)=Unk
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 15875779
Title Cytotoxic effect of Laxaphycins A and B on human lymphoblastic cells (CCRF-CEM) using digitised videomicrofluorometry
Doi Not available
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.