Peptide Libraray

sesquin

General Information

DCTPep ID DCTPep00136

Peptide Name sesquin

Sequence KTCENLADTY

Sequence Length 10

UniProt ID Not available

PubChem CID Not available

Origin Ground beans

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
M1	Mouse myeloid leukemia	70%Inhibition=0.5mg/ml	MTT assay	24 h	1
MCF-7	Invasive breast carcinoma of no special type	85%Inhibition=0.5mg/ml	MTT assay	24 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C48H76N12O19S1

Absent amino acids FGHIMPQRSVW

Theoretical pI 4.37

Acidic residues 2

Basic residues 1

Polar residues 5

Molecular weight (Average) 1157.26

Molecular weight (Monoisotopic) 1156.51

Common amino acids T

Net charge -1

Instability index (II) -14.52

Aliphatic index 49.00

Grand average of hydropathicity (GRAVY) -0.900

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.288, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.288, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 15949629

Title Sesquin, a potent defensin-like antimicrobial peptide from ground beans with inhibitory activities toward tumor cells and HIV-1 reverse transcriptase

Doi 10.1016/j.peptides.2005.01.003

Year 2005

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available