Peptide Libraray

Cherimolacyclopeptide E

General Information

DCTPep ID DCTPep00144

Peptide Name Cherimolacyclopeptide E

Sequence PGLGFY

Sequence Length 6

UniProt ID P85003

PubChem CID Not available

Origin Annona cherimola (Custard apple) (Cherimoya)

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Human nasopharyngeal carcinoma	Nasopharyngeal carcinoma	IC50=0.017 µM	Methylene Blue colourimetric assay	72h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond NCB: Pro1<--->Tyr6

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C33H44N6O8

Absent amino acids ACDEHIKMNQRSTVW

Theoretical pI 5.95

Acidic residues 0

Basic residues 0

Polar residues 3

Molecular weight (Average) 652.75

Molecular weight (Monoisotopic) 652.32

Common amino acids G

Net charge 0

Instability index (II) 62.67

Aliphatic index 65.00

Grand average of hydropathicity (GRAVY) 0.483

Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 2.283

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 16040066

Title Two cyclopeptides from the seeds of Annona cherimola

Doi 10.1016/j.phytochem.2005.06.011

Year 2005

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_2979