This work is licensed under a Creative Commons Attribution 4.0 International License.
Tyroserleutide
General Information
DCTPep ID DCTPep00145
Peptide Name Tyroserleutide
Sequence YSL
Sequence Length 3
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| BEL-7402 | Human papillomavirus-related endocervical adenocarcinoma | 20.8% cytotoxic at 1 µg/ml | MTT assay | 96 h | 1 |
| BEL-7402 | Human papillomavirus-related endocervical adenocarcinoma | 33.8% cytotoxic at 10 µg/ml | MTT assay | 96 h | 1 |
| BEL-7402 | Human papillomavirus-related endocervical adenocarcinoma | 35.6% cytotoxic at 100 µg/ml | MTT assay | 96 h | 1 |
| BEL-7402 | Human papillomavirus-related endocervical adenocarcinoma | 39.0% cytotoxic at 0.1 µg/ml | MTT assay | 96 h | 1 |
| B16-F10 | Mouse melanoma | 49.4% cytotoxic at 0.1 µg/ml | MTT assay | 96 h | 1 |
| B16-F10 | Mouse melanoma | 51.2% cytotoxic at 1 µg/ml | MTT assay | 96 h | 1 |
| B16-F10 | Mouse melanoma | 53.0% cytotoxic at 10 µg/ml | MTT assay | 96 h | 1 |
| B16-F10 | Mouse melanoma | 61.2% cytotoxic at 100 µg/ml | MTT assay | 96 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Enhances the antitumor effects of macrophages and stimulates macrophage secretion of IL-1β, TNF-α, and NO in vitro
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16091933
Title Tripeptide tyroserleutide enhances the antitumor effects of macrophages and stimulates macrophage secretion of IL-1beta, TNF-alpha, and NO in vitro
Doi 10.1007/s00262-005-0024-10
Year 2006
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.