Peptide Libraray

lunatusin

General Information

DCTPep ID DCTPep00148

Peptide Name lunatusin

Sequence KTCENLADTFRGPCFATSNC

Sequence Length 20

UniProt ID Not available

PubChem CID Not available

Origin Phaseolus lunatus

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MCF-7	Invasive breast carcinoma of no special type	IC50=5.71 µM	MTT assay	4 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00148

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C90H140N26O31S3

Absent amino acids HIMQVWY

Theoretical pI 6.05

Acidic residues 2

Basic residues 2

Polar residues 10

Molecular weight (Average) 2178.44

Molecular weight (Monoisotopic) 2176.93

Common amino acids CT

Net charge 0

Instability index (II) -5.54

Aliphatic index 29.50

Grand average of hydropathicity (GRAVY) -0.340

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.057, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 16269344

Title Lunatusin, a trypsin-stable antimicrobial peptide from lima beans (Phaseolus lunatus L.)

Doi 10.1016/j.peptides.2005.03.004

Year 2005

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available