This work is licensed under a Creative Commons Attribution 4.0 International License.
LL-37(17-29)
General Information
DCTPep ID DCTPep00155
Peptide Name LL-37(17-29)
Sequence FKRIVQRIKDFLR
Sequence Length 13
UniProt ID P49913
PubChem CID 102602727
Origin LL-37,a series of peptide fragments
Type Synthetic peptide
Classification
ACP Tumor active peptide Induce apoptosis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | IC50=20.1 μg/ml | MTT assay | 24 h | 2 |
| KB | Human papillomavirus-related endocervical adenocarcinoma | LC50=57 µM | MTT assay | 24 h | 1 |
| KBv | Human oral carcinoma | LC50=60 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: Not active up to 500 µg/ml
Normal (non-cancerous) Cytotoxicity HBMEC: LC50=41 µM; DLF lung fibroblasts: IC50=29.3 μg/ml
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 2FBS
Predicted Structure DCTPep00155
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C80H135N25O17
Absent amino acids ACEGHMNPSTWY
Theoretical pI 11.72
Acidic residues 1
Basic residues 5
Polar residues 0
Molecular weight (Average) 1719.11
Molecular weight (Monoisotopic) 1718.05
Common amino acids R
Net charge 4
Instability index (II) 18.7
Aliphatic index 112.31
Grand average of hydropathicity (GRAVY) -0.438
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16637646
Title Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region
Year 2005
Literature 2
Pubmed ID 32567085
Title Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents
Doi 10.1002/psc.3254
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
This work is licensed under a Creative Commons Attribution 4.0 International License.