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LL-37(13-37)
General Information
DCTPep ID DCTPep00156
Peptide Name LL-37(13-37)
Sequence IGKEFKRIVQRIKDFLRNLVPRTES
Sequence Length 25
PubChem CID 102602726
Origin LL-37,a series of peptide fragments
Type Synthetic peptide
Classification
ACP Tumor active peptide Induce apoptosis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| KBv | Human oral carcinoma | LC50=39 µM | MTT assay | 24 h | 1 |
| KB | Human papillomavirus-related endocervical adenocarcinoma | LC50=40 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HBMEC: LC50=38±3 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID 2FCG
Predicted Structure DCTPep00156
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C137H232N42O36
Absent amino acids ACHMWY
Theoretical pI 10.93
Acidic residues 3
Basic residues 7
Polar residues 4
Molecular weight (Average) 3043.61
Molecular weight (Monoisotopic) 3041.76
Common amino acids R
Net charge 4
Instability index (II) 36.16
Aliphatic index 101.20
Grand average of hydropathicity (GRAVY) -0.624
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16637646
Title Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
This work is licensed under a Creative Commons Attribution 4.0 International License.