Peptide Libraray

OGF, 7

General Information

DCTPep ID DCTPep00158

Peptide Name OGF, 7

Sequence YGGFM

Sequence Length 5

UniProt ID Not available

PubChem CID Not available

Origin The native opioid growth factor

Type Native peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HBL	Melanoma	0.4% inhibition at 1μM, 1% inhibition at 10μM, 4.5% inhibition at 100μM, 10.8% inhibition at 1000μM	MTT assay	72 h	1
HT-29	Colon adenocarcinoma	14% inhibition at 1μM, 15.9% inhibition at 10μM, 16.1% inhibition at 100μM, 19.3% inhibition at 1000μM	MTT assay	72 h	1
SW620	Colon adenocarcinoma	18.9% inhibition at 1μM, 12.7% inhibition at 10μM, 15.3% inhibition at 100μM, 19.1% inhibition at 1000μM	MTT assay	72 h	1
HeLa	Human papillomavirus-related endocervical adenocarcinoma	2.3% inhibition at 1μM, 11.4% inhibition at 10μM, 12% inhibition at 100μM, 22.3% inhibition at 1000μM	MTT assay	72 h	1
MCF-7	Invasive breast carcinoma of no special type	3.6% inhibition at 1μM, 4.1% inhibition at 10μM, 7.6% inhibition at 100μM, 15.4% inhibition at 1000μM	MTT assay	72 h	1
CaCo-2	Colon adenocarcinoma	4.2% inhibition at 1μM, 6.4% inhibition at 10μM, 8.4% inhibition at 100μM, 3.2% inhibition at 1000μM	MTT assay	72 h	1
HEp-2	Human papillomavirus-related endocervical adenocarcinoma	5.2% inhibition at 1μM, 4.5% inhibition at 10μM, 2.4% inhibition at 100μM, 3.3% inhibition at 1000μM	MTT assay	72 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism lead to apoptosis

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 16722632

Title Tumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity

Doi 10.1021/jm051026

Year +2006

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available