8

General Information


DCTPep ID  DCTPep00159

Peptide Name   8

Sequence  YX

Sequence Length  2

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma 10% inhibition at 10μM, 8.2% inhibition at 100μM, 36.1% inhibition at 1000μM MTT assay 72 h 1
SW620 Colon adenocarcinoma 12.9% inhibition at 1μM, 16.5% inhibition at 10μM, 28.1% inhibition at 100μM, 58.2% inhibition at 1000μM MTT assay 72 h 1
HEp-2 Human papillomavirus-related endocervical adenocarcinoma 14.2% inhibition at 1μM, 19.7% inhibition at 10μM, 24.9% inhibition at 100μM, 30.4% inhibition at 1000μM MTT assay 72 h 1
MCF-7 Invasive breast carcinoma of no special type 2.4% inhibition at 10μM, 7.5% inhibition at 1000μM MTT assay 72 h 1
CaCo-2 Colon adenocarcinoma 3.5% inhibition at 1μM, 22.7% inhibition at 10μM, 18.9% inhibition at 100μM, 26.4% inhibition at 1000μM MTT assay 72 h 1
HBL Melanoma 6.5% inhibition at 1μM, 14% inhibition at 10μM, 7.5% inhibition at 100μM, 14% inhibition at 1000μM MTT assay 72 h 1
HT-29 Colon adenocarcinoma 9.8% inhibition at 1μM, 1.6% inhibition at 10μM, 5.4% inhibition at 100μM, 26.5% inhibition at 1000μM MTT assay 72 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  lead to apoptosis



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X=Cαα -dialkylated glycine (Aaa1 )

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 16722632

Title  Tumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity

Doi 10.1021/jm051026

Year  +2006

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.