This work is licensed under a Creative Commons Attribution 4.0 International License.
23
General Information
DCTPep ID DCTPep00166
Peptide Name 23
Sequence YGGFMX
Sequence Length 6
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| CaCo-2 | Colon adenocarcinoma | 11.8% inhibition at 10μM, 47.0% inhibition at 1000μM | MTT assay | 72 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | 2.2% inhibition at 1μM, 7.1% inhibition at 10μM, 6.9% inhibition at 100μM, 25.9% inhibition at 1000μM | MTT assay | 72 h | 1 |
| HEp-2 | Human papillomavirus-related endocervical adenocarcinoma | 3.9% inhibition at 10μM, 45.0% inhibition at 1000μM | MTT assay | 72 h | 1 |
| HBL | Melanoma | 4.1% inhibition at 1μM, 70.7% inhibition at 10μM, 34.2% inhibition at 1000μM | MTT assay | 72 h | 1 |
| HT-29 | Colon adenocarcinoma | 9.2% inhibition at 1000μM | MTT assay | 72 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | 9.3% inhibition at 1000μM | MTT assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism lead to apoptosis
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=Cαα -dialkylated glycine (Aaa1 )
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16722632
Title Tumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity
Doi 10.1021/jm051026
Year +2006
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
This work is licensed under a Creative Commons Attribution 4.0 International License.