This work is licensed under a Creative Commons Attribution 4.0 International License.
Gaegurin 5 (1-11)[V8W]
General Information
DCTPep ID DCTPep00168
Peptide Name Gaegurin 5 (1-11)[V8W]
Sequence FLGALFKWASK
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| NCI-H630 | Rectal carcinoma | IC50=129.54 µg/ml | MTT assay | 3 days | 1 |
| MKN 45 | Gastric adenocarcinoma | IC50=142.72 µg/ml | MTT assay | 3 days | 1 |
| HCT 116 | Colon carcinoma | IC50=144.37 µg/ml | MTT assay | 3 days | 1 |
| SK-OV-3 | Ovarian serous cystadenocarcinoma | IC50=150.45 µg/m | MTT assay | 3 days | 1 |
| PC-3 | Prostate carcinoma | IC50=174.15 µg/ml | MTT assay | 3 days | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=198.87 µg/ml | MTT assay | 3 days | 1 |
| A498 | Renal cell carcinoma | IC50=214.33 µg/ml | MTT assay | 3 days | 1 |
| A549 | Lung adenocarcinoma | IC50=418.15 µg/ml | MTT assay | 3 days | 1 |
Hemolytic Activity Human erythrocytes: 7% Hemolysis=100 µg/ml
Normal (non-cancerous) Cytotoxicity MCF-10a: IC50=434.79 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C64H94N14O13
Absent amino acids CDEHIMNPQRTVY
Theoretical pI 10.00
Acidic residues 0
Basic residues 2
Polar residues 2
Molecular weight (Average) 1267.54
Molecular weight (Monoisotopic) 1266.71
Common amino acids AFKL
Net charge 2
Instability index (II) -25.95
Aliphatic index 89.09
Grand average of hydropathicity (GRAVY) 0.627
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 4.339
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16884301
Title Structural determinants for the membrane interaction of novel bioactive undecapeptides derived from gaegurin 5
Year 2006
Literature 2
Pubmed ID 14739294
Title Systematic peptide engineering and structural characterization to search for the shortest antimicrobial peptide analogue of gaegurin 5
Year 2004
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.