DCTPep ID  DCTPep00170

Peptide Name   Brevinin-Alb

Sequence  FLPLAVSLAANFLPKLFCKITKKC

Sequence Length  24

UniProt ID  Not available

PubChem CID  Not available

Origin  Amolops loloensis; Amolops jingdongensis

Type  Native peptide

Hemolytic Activity  Rabbit erythrocytes: 50% Hemolysis=5 µg/ml; 96% Hemolysis=20 µg/ml

Normal (non-cancerous) Cytotoxicity  Rat mast cells: 17% degranulation=100 µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available

PDB ID  Not available

Predicted Structure  DCTPep00170

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys18<--->Cys24

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L

Grand average of hydropathicity (GRAVY)  0.946

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 125
  Abs 0.1% (=1 g/l) 0.047, assuming all pairs of Cys residues form cystines
  Ext. coefficient 0
  Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced

Amino acid distribution

Literature 1

Pubmed ID 17000029

Title  Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis

Doi 10.1016/j.peptides.2006.08.017

Year  2006

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available