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Cytotoxin drCT-1 (drCT-I)
General Information
DCTPep ID DCTPep00171
Peptide Name Cytotoxin drCT-1 (drCT-I)
Sequence LKCNKLVPLFYKTCPAGKNL
Sequence Length 20
UniProt ID P0C5H4
PubChem CID Not available
Origin Daboia russelii (Russel's viper) (Vipera russelii)
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | IC50=6.7μg/ml | MTT assay | 24h | 1 |
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | IC50=8.9μg/ml | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00171
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Not available
C-terminal Modification Not available
Other Modification None
Chiral L
Physicochemical Information
Formula C104H172N26O25S2
Absent amino acids DEHIMQRSW
Theoretical pI 9.60
Acidic residues 0
Basic residues 4
Polar residues 7
Molecular weight (Average) 2250.79
Molecular weight (Monoisotopic) 2249.24
Common amino acids KL
Net charge 4
Instability index (II) 53.8
Aliphatic index 97.50
Grand average of hydropathicity (GRAVY) 0.040
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1615
Abs 0.1% (=1 g/l) 0.718, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.662, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17055549
Title A heat stable protein toxin (drCT-I) from the Indian Viper (Daboia russelli russelli) venom having antiproliferative, cytotoxic and apoptotic activities
Doi 10.1016/j.toxicon.2006.09.009
Year 2006
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.