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Odorranain-C1
General Information
DCTPep ID DCTPep00178
Peptide Name Odorranain-C1
Sequence GVLGAVKDLLIGAGKSAAQSVLKTLSCKLSNDC
Sequence Length 33
UniProt ID Not available
PubChem CID Not available
Origin Odorrana grahami
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | IC50=27.31 µM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=41.21 µM | MTT assay | 24h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=52.83 µM | MTT assay | 24h | 1 |
| LoVo | Colon adenocarcinoma | IC50=55.22 µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: 0% Hemolysis=50 µg/ml; Sheep erythrocytes: <10% Hemolysis=256 µM
Normal (non-cancerous) Cytotoxicity Human mast cells: 2.9±1.5% degranulation=50 µg/ml; HEK293T: IC50=48.7 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00178
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys27<--->Cys33
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C140H247N39O45S2
Absent amino acids EFHMPRWY
Theoretical pI 8.82
Acidic residues 2
Basic residues 4
Polar residues 12
Molecular weight (Average) 3260.86
Molecular weight (Monoisotopic) 3258.77
Common amino acids L
Net charge 2
Instability index (II) 19.15
Aliphatic index 121.21
Grand average of hydropathicity (GRAVY) 0.515
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.038, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34073203
Title Prediction of Anticancer Peptides with High Efficacy and Low Toxicity by Hybrid Model Based on 3D Structure of Peptides
Year 2021
Literature 2
Pubmed ID 17272268
Title Anti-infection peptidomics of amphibian skin
Doi 10.1074/mcp.M600334-MCP200
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.