Peptide Libraray

NK23c

General Information

DCTPep ID DCTPep00179

Peptide Name NK23c

Sequence KILRGVSKKIMRTFLRRILTGKK

Sequence Length 23

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Not active up to 100 µg/ml	MTT assay	24h	1

Hemolytic Activity Human erythrocytes: 15% Hemolysis=100 µg/ml

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00179

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C124H228N40O27S1

Absent amino acids ACDEHNPQWY

Theoretical pI 12.49

Acidic residues 0

Basic residues 9

Polar residues 5

Molecular weight (Average) 2743.49

Molecular weight (Monoisotopic) 2741.74

Common amino acids K

Net charge 9

Instability index (II) 51.6

Aliphatic index 114.35

Grand average of hydropathicity (GRAVY) -0.291

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 17389605

Title Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens

Doi 10.1074/jbc.M608920200

Year 2007

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available