C7S/NK27-COOH

General Information


DCTPep ID  DCTPep00181

Peptide Name   C7S/NK27-COOH

Sequence  KILRGVSKKIMRTFLRRISKDILTGKK

Sequence Length  27

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Membrane lysis



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma (6.5±17.3)% Cytotoxicity=100 µg/ml MTT assay 24h 1

Hemolytic Activity  Human erythrocytes: <5% Hemolysis=100 µg/ml

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00181

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C143H261N45O34S1

Absent amino acids  ACEHNPQWY

Theoretical pI  12.02

Acidic residues  1

Basic residues  10

Polar residues  6

Molecular weight (Average)  3186.99

Molecular weight (Monoisotopic)  3184.98

Common amino acids  K

Net charge  9

Instability index (II)  45.43

Aliphatic index  111.85

Grand average of hydropathicity (GRAVY)  -0.385

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 17389605

Title  Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens

Doi 10.1074/jbc.M608920200

Year  2007

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_5048

DCTPep is developed by Dr.Zheng's team.