This work is licensed under a Creative Commons Attribution 4.0 International License.
C7S/NK27-COOH
General Information
DCTPep ID DCTPep00181
Peptide Name C7S/NK27-COOH
Sequence KILRGVSKKIMRTFLRRISKDILTGKK
Sequence Length 27
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Membrane lysis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | (6.5±17.3)% Cytotoxicity=100 µg/ml | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: <5% Hemolysis=100 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00181
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C143H261N45O34S1
Absent amino acids ACEHNPQWY
Theoretical pI 12.02
Acidic residues 1
Basic residues 10
Polar residues 6
Molecular weight (Average) 3186.99
Molecular weight (Monoisotopic) 3184.98
Common amino acids K
Net charge 9
Instability index (II) 45.43
Aliphatic index 111.85
Grand average of hydropathicity (GRAVY) -0.385
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17389605
Title Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_5048
This work is licensed under a Creative Commons Attribution 4.0 International License.