Peptide Libraray

NK23a

General Information

DCTPep ID DCTPep00182

Peptide Name NK23a

Sequence KISKKIMRTFLRRISKDILTGKK

Sequence Length 23

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Not active up to 100 µg/ml	MTT assay	24h	1

Hemolytic Activity Human erythrocytes: <5% Hemolysis=100 µg/ml

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00182

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C124H226N38O30S1

Absent amino acids ACEHNPQVWY

Theoretical pI 11.76

Acidic residues 1

Basic residues 9

Polar residues 5

Molecular weight (Average) 2761.46

Molecular weight (Monoisotopic) 2759.7

Common amino acids K

Net charge 8

Instability index (II) 38.54

Aliphatic index 101.74

Grand average of hydropathicity (GRAVY) -0.587

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 17389605

Title Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens

Doi 10.1074/jbc.M608920200

Year 2007

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available